Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule
binding assays have been introduced to address this problem. How compounds …

Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding
proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly and …

Motivation Antimicrobial resistance (AMR) is becoming a huge problem in both developed
and developing countries, and identifying strains resistant or susceptible to certain antibiotics …

… RBPs are color-coded with their annotated binding feature. Rows are labeled by their respective
… To determine the top targets for SLBP we first ranked all peaks by their P value and then …

Technology for crosslinking and immunoprecipitation (CLIP) followed by sequencing (CLIP-seq)
has identified the transcriptomic targets of hundreds of RNA-binding proteins in cells. To …

Cell-cell interactions shape cellular function and ultimately organismal phenotype.
Interacting cells can sense their mutual distance using combinations of ligand-receptor pairs, …

RNA-binding proteins (RBPs) modulate alternative splicing outcomes to determine isoform
expression and cellular survival. To identify RBPs that directly drive alternative exon inclusion…

Background Discerning genes crucial to antimicrobial resistance (AMR) mechanisms is
becoming more and more important to accurately and swiftly identify AMR pathogenic strains. …

Disease of the heart accounts for 6% of all death. Heart sound is a routine in physical examination
clinically, and is sensitive in detecting a subset of heart diseases. In the current study, …

Motivation Cross-linking and immunoprecipitation (CLIP) is a technology to map the binding
sites of RNA-binding proteins (RBPs). The region where an RBP binds within RNA is often …