Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
Intramyocardial injection of adult bone marrow–derived stem cells has recently been
proposed as a potential therapy to repair damaged myocardium after acute infarction1–4. The …
proposed as a potential therapy to repair damaged myocardium after acute infarction1–4. The …
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
Transplantation of adult bone marrow–derived mesenchymal stem cells has been proposed
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …
Evidence supporting paracrine hypothesis for Akt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement
We previously reported that intramyocardial injection of bone marrow‐derived mesenchymal
stem cells overexpressing Akt (Akt‐MSCs) inhibits ventricular remodeling and restores …
stem cells overexpressing Akt (Akt‐MSCs) inhibits ventricular remodeling and restores …
[PDF][PDF] Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Skeletal and cardiac muscle depend on high turnover of ATP made by mitochondria in order
to contract efficiently. The transcriptional coactivator PGC-1α has been shown to function as …
to contract efficiently. The transcriptional coactivator PGC-1α has been shown to function as …
[HTML][HTML] Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
B Zhou, LB Honor, H He, Q Ma, JH Oh… - The Journal of …, 2011 - Am Soc Clin Investig
The epicardium makes essential cellular and paracrine contributions to the growth of the
fetal myocardium and the formation of the coronary vasculature. However, whether the …
fetal myocardium and the formation of the coronary vasculature. However, whether the …
An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics
As a common feature in a majority of malignant tumors, hypoxia has become the Achilles’
heel of photodynamic therapy (PDT). The development of type‐I photosensitizers that show …
heel of photodynamic therapy (PDT). The development of type‐I photosensitizers that show …
Bioinspired hybrid protein oxygen nanocarrier amplified photodynamic therapy for eliciting anti-tumor immunity and abscopal effect
An ideal cancer therapeutic strategy is expected to possess potent ability to not only ablate
primary tumors but also prevent distance metastasis and relapse. In this study, human serum …
primary tumors but also prevent distance metastasis and relapse. In this study, human serum …
Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@ manganese dioxide to inhibit tumor growth and metastases
Metastatic triple-negative breast cancer (mTNBC) is an aggressive disease among women
worldwide, characterized by high mortality and poor prognosis despite systemic therapy with …
worldwide, characterized by high mortality and poor prognosis despite systemic therapy with …
Oncomodulin links inflammation to optic nerve regeneration
…, Z Li, C Zaverucha-do-Valle, H He… - Proceedings of the …, 2009 - National Acad Sciences
The inflammatory response that accompanies central nervous system (CNS) injury can
affect neurological outcome in both positive and negative ways. In the optic nerve, a CNS …
affect neurological outcome in both positive and negative ways. In the optic nerve, a CNS …
In Situ photocatalyzed oxygen generation with photosynthetic bacteria to enable robust immunogenic photodynamic therapy in triple‐negative breast cancer
Hypoxia in the tumor microenvironment is a major hurdle dampening the antitumor effect of
photodynamic therapy (PDT). Herein, active photosynthetic bacteria (Synechococcus 7942, …
photodynamic therapy (PDT). Herein, active photosynthetic bacteria (Synechococcus 7942, …