Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

HIV-1 escapes antiretroviral agents by integrating into the host DNA and forming a latent
transcriptionally silent HIV-1 provirus. Transcriptional activation is prerequisite for reactivation …

HIV-infected individuals currently cannot be completely cured because existing antiviral
therapy regimens do not address HIV provirus DNA, flanked by long terminal repeats (LTRs), …

The hepatitis B virus X (HBx) protein is thought to be implicated in the development of
human hepatocellular carcinoma (HCC), but its exact function remains controversial. To …

The massive and rapid transmission of SARS-CoV-2 has led to the emergence of several
viral variants of concern (VOCs), with the most recent one, B.1.1.529 (Omicron), which …

None of the currently used anti-HIV-1 agents can effectively eliminate latent HIV-1 reservoirs,
which is a major hurdle to a complete cure for AIDS. We report here that a novel oral BET …

Chimeric antigen receptor (CAR) T cell therapy faces a number of challenges for the treatment
of non-small-cell lung carcinoma (NSCLC), and efficient migration of circulating CAR T …

Persistent latent reservoir in resting CD4+ T cells is a major obstacle in curing HIV-1 infection.
Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We report …

Cells harboring latent HIV-1 pose a major obstacle to eradication of the virus. The ‘shock and
kill’strategy has been broadly explored to purge the latent reservoir; however, none of the …

The latent HIV ‐1 reservoir is a major barrier to viral eradication. However, our understanding
of how HIV ‐1 establishes latency is incomplete. Here, by performing a genome‐wide …