Seasonal variations in soil respiration, heterotrophic respiration and autotrophic respiration of a wheat and maize rotation cropland in the North China Plain
Determining soil respiration from croplands is necessary for evaluating the global terrestrial
carbon budget and how it is altered in future climates. This study explored seasonal …
carbon budget and how it is altered in future climates. This study explored seasonal …
Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer
KR Zhang, YF Zhang, HM Lei, YB Tang… - Science translational …, 2021 - science.org
Acquired resistance represents a bottleneck to molecularly targeted therapies such as epidermal
growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in lung cancer. A …
growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in lung cancer. A …
NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells
…, K Zhang, Y Tang, Y Zhang, Y Shen, H Lei… - Acta Pharmacologica …, 2021 - nature.com
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have achieved
satisfactory clinical effects in the therapy of non-small cell lung cancer (NSCLC), but acquired …
satisfactory clinical effects in the therapy of non-small cell lung cancer (NSCLC), but acquired …
Seasonal and interannual variations in carbon dioxide exchange over a cropland in the North China Plain
HUIMIN LEI, DAWEN YANG - Global change biology, 2010 - Wiley Online Library
In China, croplands account for a relatively large form of vegetation cover. Quantifying carbon
dioxide exchange and understanding the environmental controls on carbon fluxes over …
dioxide exchange and understanding the environmental controls on carbon fluxes over …
[PDF][PDF] A novel allosteric inhibitor of phosphoglycerate mutase 1 suppresses growth and metastasis of non-small-cell lung cancer
Phosphoglycerate mutase 1 (PGAM1) plays a pivotal role in cancer metabolism and tumor
progression via its metabolic activity and interaction with other proteins like α-smooth muscle …
progression via its metabolic activity and interaction with other proteins like α-smooth muscle …
Metabolic and nonmetabolic functions of PSAT1 coordinate signaling cascades to confer EGFR inhibitor resistance and drive progression in lung adenocarcinoma
…, Y Zhou, WM Gu, C Wang, NX Shen, JK Dong, HM Lei… - Cancer Research, 2022 - AACR
Metabolic and nonmetabolic functions of PSAT1 confer EGFR inhibitor resistance and
promote metastasis in lung adenocarcinoma, suggesting therapeutic targeting of PSAT1 may …
promote metastasis in lung adenocarcinoma, suggesting therapeutic targeting of PSAT1 may …
[HTML][HTML] Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase
JK Dong, HM Lei, Q Liang, YB Tang, Y Zhou… - Theranostics, 2018 - ncbi.nlm.nih.gov
How to improve the efficacy and reverse the resistance to epidermal growth factor receptor
tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib, remains a major challenge in the …
tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib, remains a major challenge in the …
[HTML][HTML] A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in …
…, L Jiang, C Wang, N Shen, M Zhang, L Xu, H Lei… - Drug Resistance …, 2023 - Elsevier
Resistance to epidermal growth factor receptor (EGFR) inhibitors, from the first-generation
erlotinib to the third generation osimertinib, is a clinical challenge in the treatment of patients …
erlotinib to the third generation osimertinib, is a clinical challenge in the treatment of patients …
[HTML][HTML] Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung …
HM Lei, KR Zhang, CH Wang, Y Wang, GL Zhuang… - Theranostics, 2019 - ncbi.nlm.nih.gov
Background: Acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase
inhibitors (TKIs) such as erlotinib is a major challenge to achieve an overall clinical benefit …
inhibitors (TKIs) such as erlotinib is a major challenge to achieve an overall clinical benefit …
Development and validation of a rapid, robust and sensitive UPLC-QQQ-MS/MS method for simultaneous quantification of GSH metabolism in lung cancer cells
YF Zhang, Y Wang, KR Zhang, HM Lei, YB Tang… - … of chromatography B, 2020 - Elsevier
Abstract Changes in cellular metabolism accompany tumor therapeutic resistance.
Metabolite concentrations specifically reflect the cellular state. Glutathione (GSH) metabolism …
Metabolite concentrations specifically reflect the cellular state. Glutathione (GSH) metabolism …