Discovery of sandwich type COVID-19 nucleocapsid protein DNA aptamers

L Zhang, X Fang, X Liu, H Ou, H Zhang… - Chemical …, 2020 - pubs.rsc.org
Here, we report for the first time DNA aptamers targeted toward the COVID-19 nucleocapsid
protein (Np). Np is one of the most abundant structural proteins and it serves as a diagnostic …

Second generation of signaling-probe displacement electrochemical aptasensor for detection of picomolar ampicillin and sulfadimethoxine

Z Yang, X Ding, Q Guo, Y Wang, Z Lu, H Ou… - Sensors and Actuators B …, 2017 - Elsevier
The high-throughput sensors suitable for both hydrophilic and lipophilic targets are highly
desired for environmental pollutants including antibiotics. Previously we reported a signaling-…

Potent neutralization of SARS-CoV-2 by hetero-bivalent alpaca nanobodies targeting the spike receptor-binding domain

…, X Wang, C Zhao, Y Sun, P Wang, H Ou… - Journal of …, 2021 - Am Soc Microbiol
Cellular entry of SARS-CoV-2 requires the binding between the receptor-binding domain (RBD)
of the viral Spike protein and the cellular angiotensin-converting enzyme 2 (ACE2). As …

Development of a fraction collection approach in capillary electrophoresis SELEX for aptamer selection

Z Luo, H Zhou, H Jiang, H Ou, X Li, L Zhang - Analyst, 2015 - pubs.rsc.org
Aptamers have attracted much attention due to their ability to bind to target molecules with
high affinity and specificity. The development of an approach capable of efficiently generating …

Highly specific triple-fragment aptamer for optical detection of cocaine

R Zou, X Lou, H Ou, Y Zhang, W Wang, M Yuan… - RSC …, 2012 - pubs.rsc.org
For the first time an anti-cocaine aptamer was cut into three fragments, which were still able
to specifically assemble with cocaine and render the sensitive and highly selective optical …

A high-throughput surface plasmon resonance biosensor based on differential interferometric imaging

D Wang, L Ding, W Zhang, Z Luo, H Ou… - Measurement …, 2012 - iopscience.iop.org
A new high-throughput surface plasmon resonance (SPR) biosensor based on differential
interferometric imaging is reported. The two SPR interferograms of the sensing surface are …

Indirect inhibitive immunoassay for estradiol using surface plasmon resonance coupled to online in-tube SPME

H Ou, Z Luo, H Jiang, H Zhou, X Wang, C Song - Analytical letters, 2009 - Taylor & Francis
A new immunoassay method using surface plasmon resonance (SPR) coupled with online,
in-tube, solid-phase microextraction (SPME) was developed and applied to detect estradiol …

Generation, biochemical characterizations and validation of potent nanobodies derived from alpaca specific for human receptor of advanced glycation end product

…, W Zeng, HM Mengist, AJK Kombe, H Ou… - Biochemical and …, 2021 - Elsevier
A detrimental role of the receptor for the advanced glycation end product (RAGE) has been
identified in the immune response, and various pathological conditions and its V and C1 …

A real-time de-noising method applied for transient and weak biomolecular interaction analysis in surface plasmon resonance biosensing

S Zhan, C Shi, H Ou, H Song… - … Science and Technology, 2016 - iopscience.iop.org
Surface plasmon resonance (SPR) biosensing technology will likely become a type of label-free
technology for transient and weak biomolecular interaction analysis (BIA); however, it …

A novel detection method of microcystin of lake water by surface plasmon resonance technique.

HM Zhou, HC Ou, P Ren, HY Zhang… - China Environmental …, 2012 - cabdirect.org
Amount of Microcystin-LR in water was rapidly and quantitatively detected by SPR (surface
plasmon resonance) technique. After the MC-LR being immobilized on the surface of the chip…