Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II)
or of a wild-type receptor with an Ang II analog ([sarcosine 1 ,Ile 4 ,Ile 8 ]Ang II) fails to …

The seven-membrane-spanning angiotensin II type 1A receptor activates the mitogen-activated
protein kinases extracellular signal-regulated kinases 1 and 2 (ERK1/2) by distinct …

Acute stimulation of cardiac β1-adrenergic receptors (β1ARs) by norepinephrine represents
the strongest endogenous mechanism for increasing cardiac function, but long-term …

β-arrestins bind to G protein-coupled receptor kinase (GRK)-phosphorylated seven
transmembrane receptors, desensitizing their activation of G proteins, while concurrently mediating …

Autophagy is a conserved cellular process for bulk degradation of intracellular protein and
organelles in lysosomes. In contrast to elegant studies of beclin1 using mouse models and …

Focal adhesion kinase (FAK) has been implicated in the development of cancers, including
those of the breast. Nevertheless, the molecular and cellular mechanisms by which FAK …

Little is known about whether autophagic mechanisms are active in hematopoietic stem cells
(HSCs) or how they are regulated. FIP200 (200-kDa FAK-family interacting protein) plays …

β-Arrestin2 not only plays essential roles in seven membrane-spanning receptor
desensitization and internalization but also functions as a signal transducer in mitogen-activated …

The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant
rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at …

Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding …