Comprehensive analysis of DNA methylation patterns is critical for understanding the molecular
basis of many human diseases. While hundreds of PCR-based DNA methylation studies …

Conflicting results have been reported as to whether genetic variations (Val66Met and C270T)
of the brain‐derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's …

The present review explores the role of ceramides in neuronal apoptosis, as well as the recent
discovery of the signaling pathways involved in this process placing particular emphasis …

Background: Attention-deficit hyperactivity disorder (ADHD) is an important psychiatric
condition in terms of its prevalence and impact on quality of life. It has one of the highest …

Objective This work was undertaken in order to identify Parkinson's disease (PD) risk
variants in a Latino cohort, to describe the overlap in the genetic architecture of PD in Latinos …

Background Wiedemann-Rautenstrauch syndrome (WRS) is a form of segmental progeria
presenting neonatally, characterised by growth retardation, sparse scalp hair, generalised …

In recent years, it has been proposed that synaptic dysfunction may be an important etiological
factor for Alzheimer's disease (AD). This hypothesis has important implications for the …

The circadian system is responsible for the generation and maintenance of physiological
and behavioral rhythms in mammals and allows synchronization with the environment. …

Evidence has implicated apoptosis as a mechanism underlying cell demise in diverse
neurodegenerative diseases including Parkinson's disease (PD). Endogenous toxins and other …

Alterations in DNA methylation have implicated as an epigenetic event in the pathogenesis
of late-onset Alzheimer’s disease (LOAD). The objective of this work was to evaluate global …