Whether or not autophagy has a role in defence against Mycobacterium tuberculosis infection
remains unresolved. Previously, conditional knockdown of the core autophagy component …

The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon
recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of …

The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the
cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-…

Actin polymerization powers membrane deformation during many processes, including
clathrin-mediated endocytosis (CME). During CME in yeast, actin polymerization is triggered and …

Macrophages employ an array of pattern recognition receptors to detect and eliminate
intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, …

The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon
recognition of DNA derived from bacteria, viruses and tumors. To signal, the C-terminal tail (…

Synthetic lethality, the concept in which the co-occurrence of two genetic events leads to cell
death while either single event alone does not, is an attractive strategy for targeted cancer …

… The MRM of the mass transitions for I-BET151 (m/z 416.17 to 311.10), and labetalol (m/z …
and cross-linking stopped by the addition of 0.125 M glycine. Cells were then lysed in 1% SDS, …

… 1 , Huntly M Morrison … 1 , Rita M McCall … 8 , Lauren M Popov …

Macrophages employ an array of receptors to detect and eliminate intracellular pathogens
that access the cytosol. Galectins represent one such class of receptors, and activate …