User profiles for Hussain Elhasasna

Hussain Elhasasna

University of Saskatchewan
Verified email at usask.ca
Cited by 673

[HTML][HTML] A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

…, SL Banerjee, KK Bhanumathy, H Elhasasna… - Clinical Cancer …, 2023 - AACR
Purpose: Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid
development of targeted cancer therapies. Although many of these treatments produce …

[HTML][HTML] Sympathetic signaling facilitates progression of neuroendocrine prostate cancer

S Dwivedi, M Bautista, S Shrestha, H Elhasasna… - Cell death …, 2021 - nature.com
The progression of prostate cancer (PC) into neuroendocrine prostate cancer (NEPC) is a
major challenge in treating PC. In NEPC, the PC cells undergo neuroendocrine differentiation (…

[HTML][HTML] A drug repurposing screen identifies fludarabine phosphate as a potential therapeutic agent for N-MYC overexpressing neuroendocrine prostate cancers

H Elhasasna, R Khan, KK Bhanumathy… - Cells, 2022 - mdpi.com
Neuroendocrine prostate cancer (NEPC) represents a highly aggressive form of prostate
tumors. NEPC results from trans-differentiated castration-resistant prostate cancer (CRPC) with …

MEMO1 is a Metal Containing Regulator of Iron Homeostasis in Cancer Cells

…, M Ralle, M Tonelli, SA Abbas, J Patry, H Elhasasna… - bioRxiv, 2023 - biorxiv.org
Mediator of ERBB2-driven Cell Motility 1 (MEMO1) is an evolutionary conserved protein
implicated in many biological processes; however, its primary molecular function remains …

MEMO1 is a metal containing regulator of iron homeostasis in the cell

…, M Tonelli, SA Abbas, J Patry, H Elhasasna… - Available at SSRN … - papers.ssrn.com
MEMO1 is an evolutionary conserved protein implicated in many biological processes, however
its primary molecular function remains unknown. Importantly, MEMO1 is overexpressed …

[PDF][PDF] MDS and AML associated DDX41 helicase resolves R-loops to maintain genome stability

A Aggarwal - 2021 - harvest.usask.ca
DNA damage and aberrant DNA damage response (DDR) are significant features of
genomic instability that are implicated in the pathogenesis of myelodysplastic syndromes (MDS) …

Anti-Colon Cancer Effect of Origanum Majorana Essential Oil

ANR Alrashedi - 2018 - scholarworks.uaeu.ac.ae
… I extend a special thanks to all my lab mates, Halima Alsamri, Nehla Benhalilou and, Hussain
Elhasasna for their help and for sharing with me the good days and the not so good day. I …

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

M Jain, C Arvanitis, K Chu, W Dewey, E Leonhardt… - Science, 2002 - science.org
Pharmacological inactivation of oncogenes is being investigated as a possible therapeutic
strategy for cancer. One potential drawback is that cessation of such therapy may allow …

Probing biological activities of RNA-binding proteins from bacterial and mammalian cells

Y Wu - 2023 - publikationen.sulb.uni-saarland.de
The growing danger of antimicrobial resistance and the ongoing fight against cancer present
an immense challenge for public health. The need for new and innovative treatments is …

[HTML][HTML] Strategies to target the cancer driver MYC in tumor cells

LI Weber, M Hartl - Frontiers in Oncology, 2023 - frontiersin.org
The MYC oncoprotein functions as a master regulator of cellular transcription and furthermore
executes non-transcriptional tasks relevant for DNA replication and cell cycle regulation, …