The small molecule APR‐246 (PRIMA‐1 MET ) is a novel drug that restores the activity of
mutated and unfolded TP53 protein. However, the mechanisms of action and potential off‐…

Background Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS
strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this …

CCTC-binding factor (CTCF) is a key regulator of gene expression through organization of
the chromatin structure. Still, it is unclear how CTCF binding is perturbed in leukemia or in …

Background Previously we have identified a distal region of the rainbow trout (Oncorhynchus
mykiss) metallothionein-A (rtMT-A) enhancer region, being essential for free radical …

The introduction of next generation sequencing (NGS) techniques has revolutionized the
genetic characterization of malignant diseases. Still, optimal determination of somatic …

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA associated
with the promotion of several solid cancers. As part of the FANTOM6 project, we aimed to …

Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises
from immature myeloid progenitors. Consequently, this leads to excessive accumulation …

Acute Myeloid Leukemia (AML) is the most common myeloid leukemia in adults. Although
substantial progress has been made in recent years, the long-term prognosis for patients …

DNA methylation is a critical regulator of cis-regulatory elements that can impact the distribution
of epigenetic regulators and transcription factors. We have mapped DNA methylation …

Traffic estimation using probe vehicle data is a crucial aspect of traffic management as it
provides real-time information about traffic conditions. This study introduced a novel framework …