[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
…, KJ Dawson, N Mende, EF Calderbank, H Jung… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity 1 ,
cytopenias 2 , immune dysfunction 3 and increased risk of blood cancer 4 , 5 – 6 , but the …
cytopenias 2 , immune dysfunction 3 and increased risk of blood cancer 4 , 5 – 6 , but the …
Intron retention is a widespread mechanism of tumor-suppressor inactivation
A substantial fraction of disease-causing mutations are pathogenic through aberrant splicing.
Although genome profiling studies have identified somatic single-nucleotide variants (SNVs…
Although genome profiling studies have identified somatic single-nucleotide variants (SNVs…
Nanochannel electroporation delivers precise amounts of biomolecules into living cells
…, A Morss, W Liao, B Henslee, HC Jung… - Nature …, 2011 - nature.com
Many transfection techniques can deliver biomolecules into cells, but the dose cannot be
controlled precisely. Delivering well-defined amounts of materials into cells is important for …
controlled precisely. Delivering well-defined amounts of materials into cells is important for …
[HTML][HTML] DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
Mitotic cell division increases tumour mutation burden and copy number load, predictive
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …
Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer
…, BW Brannigan, BS Wittner, H Jung… - Proceedings of the …, 2015 - National Acad Sciences
Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a
wide variety of epithelial cancers. In deriving experimental systems to study its deregulation…
wide variety of epithelial cancers. In deriving experimental systems to study its deregulation…
[PDF][PDF] Somatic evolution in non-neoplastic IBD-affected colon
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased
risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 …
risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 …
[HTML][HTML] Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease
…, MF Ciuculescu, EB Esrick, E Mitchell, H Jung… - Nature Medicine, 2023 - nature.com
Gene therapy (GT) provides a potentially curative treatment option for patients with sickle cell
disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials has …
disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials has …
[HTML][HTML] Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision
repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic …
repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic …
[HTML][HTML] APOBEC mutagenesis is a common process in normal human small intestine
APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer types.
However, there is an incomplete understanding of its stimulus, when it occurs in the …
However, there is an incomplete understanding of its stimulus, when it occurs in the …
Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens
The utilization of archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for massive
parallel sequencing has been challenging due to DNA damage and contamination with …
parallel sequencing has been challenging due to DNA damage and contamination with …