Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted
senescence-associated secretory phenotype (SASP). Loss of mitochondrial function …

Regulatory T cells (Tregs) can potentially migrate to the B cell areas of secondary lymphoid
tissues and suppress T cell-dependent B cell Ig response. T cell-dependent Ig response …

How Tregs migrate to GCs, and whether they regulate the helper activity of the T cells in GCs
(GC-Th cells) remains poorly understood. We found a T cell subset in human tonsils that …

In this study, we report a novel biological function of vitamin A metabolites in conversion of
naive FoxP3− CD4+ T cells into a unique FoxP3+ regulatory T cell subset (termed “retinoid-…

It is a question of interest whether Th17 cells express trafficking receptors unique to this Th
cell lineage and migrate specifically to certain tissue sites. We found several Th17 cell …

Gene expression profiling was used to compare the gene expression patterns of human
germinal center (GC) T helper (Th) cells with other CD4 + T-cell subsets (naive, central, and …

A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on
antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular complexes …

Follicular helper T cells (T FH cells) provide critical help to B cells during humoral immune
responses. Here we report that mice with T cell–specific deletion of the miR-17∼92 family of …

Forkhead Box P3+(FOXP3+) T cells are regulatory cells important for maintaining immune
tolerance. While chemokine-and other homing-receptors are important for T cell migration, it …

The balance of effector and regulatory T cell function, dependent on multiple signals and
epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) …