[HTML][HTML] miRNAs as influencers of cell–cell communication in tumor microenvironment
I Conti, G Varano, C Simioni, I Laface, D Milani… - Cells, 2020 - mdpi.com
… , miR-150, and miR-142-3p) were immunoprecipitated with AGO2, which harboured them
from serum RNAse activity, suggesting the presence of at least two ECmiRNAs populations: i) …
from serum RNAse activity, suggesting the presence of at least two ECmiRNAs populations: i) …
[PDF][PDF] Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset
of patients. Here, we applied single-cell technologies to iCD lesions to address whether …
of patients. Here, we applied single-cell technologies to iCD lesions to address whether …
[HTML][HTML] PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer
PTX3 is an essential component of the humoral arm of innate immunity, playing a nonredundant
role in resistance against selected microbes and in the regulation of inflammation. PTX3 …
role in resistance against selected microbes and in the regulation of inflammation. PTX3 …
Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent
BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …
The Y chromosome-linked copy number variations and male fertility
…, C Chianese, C Giachini, E Guarducci, I Laface… - Journal of …, 2011 - Springer
Since the first definition of the AZoospermia Factor (AZF) regions, the Y chromosome has
become an important target for studies aimed to identify genetic factors involved in male …
become an important target for studies aimed to identify genetic factors involved in male …
The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases
…, E Bonavita, S Gentile, M Rubino, I Laface… - International archives of …, 2015 - karger.com
… Similarly, PTX3 has been shown to interact with C4BP, which inhibits complement
activation by acting as a cofactor for factor I in the cleavage and inactivation of C4b [51]. This …
activation by acting as a cofactor for factor I in the cleavage and inactivation of C4b [51]. This …
An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode
…, M Stravalaci, F Pasqualini, I Laface… - Journal of Experimental …, 2015 - rupress.org
… Wound collagen was evaluated by collagen I and Sirius red staining. On day 7, collagen
content was higher in Ptx3 −/− tissues after wounding compared with WT (Fig. 2 J). …
content was higher in Ptx3 −/− tissues after wounding compared with WT (Fig. 2 J). …
MRI radiomics features predict immuno-oncological characteristics of hepatocellular carcinoma
…, J Putra, S Ward, T Higashi, S Thung, S Yao, I Laface… - European …, 2020 - Springer
Objective To assess the value of qualitative and quantitative MRI radiomics features for
noninvasive prediction of immuno-oncologic characteristics and outcomes of hepatocellular …
noninvasive prediction of immuno-oncologic characteristics and outcomes of hepatocellular …
BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology
…, H Abhyankar, M Casanova-Acebes, I Laface… - Nature medicine, 2021 - nature.com
Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by
granulomatous lesions with characteristic clonal mononuclear phagocytes (MNPs) harboring …
granulomatous lesions with characteristic clonal mononuclear phagocytes (MNPs) harboring …
Partial AZFc deletions and duplications: clinical correlates in the Italian population
The role of partial AZFc deletions of the Y chromosome in spermatogenic impairment is
currently debated. Recently, it was also reported that duplications of the same region are …
currently debated. Recently, it was also reported that duplications of the same region are …