Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with
greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary …

Brain tumor growth and tumor-induced edema result in increased intracranial pressure (ICP),
which, in turn, is responsible for conditions as benign as headaches and vomiting or as …

Glioblastomas are among the most lethal cancers, with a 5 year survival rate below 25%.
Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-…

Simple Summary Studying rare outcomes in cancer is challenging because observation of
the rare event may require a very high number of patients or experimental animals. Here, we …

The use of prostate‐specific antigen (PSA) as a prognostic indicator for prostate cancer (PCa)
patients is controversial, especially since it has been shown to correlate poorly with tumor …

Ductal carcinoma in situ (DCIS) and invasive breast cancer share many morphologic, proteomic,
and genomic alterations. Yet in contrast to invasive cancer, many DCIS tumors do not …

Background The early diagnosis of atherosclerotic disease is essential for developing preventive
strategies in populations at high risk and acting when the disease is still asymptomatic. …

Renal cell carcinoma (RCC) is one of the ten most common and lethal cancers in the United
States. Tumor heterogeneity and development of resistance to treatment suggest that patient…

Background: Despite renal impairment (RI) being a risk factor for severe COVID-19, there are
no approved antiviral treatment options for patients with severely impaired kidney function (…

Introduction. The natural history of preinvasive breast cancer, or ductal carcinoma in situ (DCIS)
remains poorly understood. Overcoming this gap would allow risk-appropriate treatment …