User profiles for I. M. Tolic

Iva M. Tolić

Ruđer Bošković Institute
Verified email at irb.hr
Cited by 8537

Self-organization and forces in the mitotic spindle

N Pavin, IM Tolić - Annual review of biophysics, 2016 - annualreviews.org
… We thank the members of the Tolić and Pavin groups and other collaborators for their
contributions to the work discussed in this review; Juraj Simunić and Lejla Ferhatović Hamzić for …

[HTML][HTML] Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles

IM Tolić - European Biophysics Journal, 2018 - Springer
… 2016a; Pavin and Tolic-Norrelykke 2014), may help the microtubules extending from the
two poles to find each other much faster than in the case without rotation (Fig. 6b). A recent …

[PDF][PDF] Mechanobiology of the mitotic spindle

N Pavin, IM Tolić - Developmental cell, 2021 - cell.com
… This movement together with a constant spindle length during metaphase implies that the
kinetochore microtubules simultaneously polymerize at the kinetochore and depolymerize at …

Modeling the insulin–glucose feedback system: the significance of pulsatile insulin secretion

IM Tolić, E Mosekilde, J Sturis - Journal of theoretical biology, 2000 - Elsevier
A mathematical model of the insulin–glucose feedback regulation in man is used to examine
the effects of an oscillatory supply of insulin compared to a constant supply at the same …

[HTML][HTML] Nuclear chromosome locations dictate segregation error frequencies

…, EM Gerrits, B Bakker, F Foijer, J Kind, IM Tolić… - Nature, 2022 - nature.com
… We thank members of the Kops, Lens and Tolić laboratories for discussions and comments
on the manuscript. Figure 3d and Extended Data Figs. 6f and 9 were created with Biorender.…

[HTML][HTML] Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

…, D Cimini, M Glunčić, N Pavin, IM Tolić - Nature …, 2016 - nature.com
During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules
that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed …

[PDF][PDF] Microtubule sliding within the bridging fiber pushes kinetochore fibers apart to segregate chromosomes

K Vukušić, R Buđa, A Bosilj, A Milas, N Pavin, IM Tolić - Developmental cell, 2017 - cell.com
During cell division, mitotic spindle microtubules segregate chromosomes by exerting
forces on kinetochores. What forces drive chromosome segregation in anaphase remains a …

PRC 1‐labeled microtubule bundles and kinetochore pairs show one‐to‐one association in metaphase

B Polak, P Risteski, S Lesjak, IM Tolić - EMBO reports, 2017 - embopress.org
In the mitotic spindle, kinetochore microtubules form k‐fibers, whereas overlap or interpolar
microtubules form antiparallel arrays containing the cross‐linker protein regulator of …

[HTML][HTML] Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

K Vukušić, I Ponjavić, R Buđa, P Risteski, IM Tolić - Developmental Cell, 2021 - Elsevier
Proper chromosome segregation into two future daughter cells requires the mitotic spindle
to elongate in anaphase. However, although some candidate proteins are implicated in this …

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

M Jagrić, P Risteski, J Martinčić, A Milas, IM Tolić - Elife, 2021 - elifesciences.org
During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …