Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad
causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is …

The neuronal ceroid lipofuscinoses (NCLs), more commonly referred to as Batten disease,
are a group of inherited lysosomal storage disorders that present with neurodegeneration, …

Dendritic cells (DC) are the major antigen-presenting cells bridging innate and adaptive
immunity, a function they perform by converting quiescent DC to active, mature DC with the …

Undifferentiated uveitis (intraocular inflammation, IOI) is an idiopathic sight-threatening,
presumed autoimmune disease, accountable for ~ 10% of all blindness in the developed world. …

Exposure of bone‐marrow‐derived dendritic cells ( BMDC ) to high‐dose ultrapure
lipopolysaccharide for 24 hr ( LPS ‐primed BMDC ) enhances their potency in preventing inter‐…

Since the plasticity and the potential for re-programming cells has become widely accepted,
there has been great interest in cell-based therapies. These are being applied to a range of …

… Accordingly, we explored whether delivery of this antibody intraperitoneally (ip) … ip delivery
(Figure 2: P60 inflammatory score sc vs isotype control p= 0.0036; P60 inflammatory score ip …

We specify the clinical features of a spontaneous experimental autoimmune uveitis (EAU)
model, in which foreign hen-egg lysozyme (HEL) is expressed in the retina, controlled by the …

The retinal vasculature is tightly organized in a structure that provides for the high metabolic
demand of neurons while minimizing interference with incident light. The adverse impact of …

Electrical gradients are present in many developing and regenerating tissues and around
tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of …