A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal
and differentiation in all stem cells. Stem cells, their progeny, and elements of their …

Stem cell differentiation and the maintenance of self-renewal are intrinsically complex
processes requiring the coordinated dynamic expression of hundreds of genes and proteins in …

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are
poorly understood. We determined global gene expression profiles for mouse and human …

… We are grateful to KA Moore and members of the Lemischka laboratory for their assistance
at various stages of these studies. We also thank A. Smith for constructive criticisms. …

We have used retrovirus-mediated gene transfer to mark hematopoietic stem cells in vitro
and have tracked the fate of these cells after their transplantation into lethally irradiated …

… conditions were as previously described (Jordan and Lemischka, … their hematopoietic
organs were harvested, and cell lineages were fractionated as described (Jordan and Lemischka, …

The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with
defined genetic disorders holds the promise of increased understanding of the aetiologies of …

To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate
genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a …

We have analyzed the temporal in vivo fate of 142 individual stem cell clones in 63
reconstituted mice. Long-term sequential analyses of the four major peripheral blood lineages, …

The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical
for self-renewal maintenance. However, it remains unclear whether these networks …