Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive
morphology and association with caveolins has led to their internalization being considered …

Genetic information flows from DNA to macromolecular structures—the dominant force in the
molecular organization of life. However, recent work suggests that metabolite availability to …

The plasma membrane is organized into various subdomains of clustered macromolecules.
Such domains include adhesive structures (cellular synapses, substrate adhesions, and cell…

The Golgi enzyme β1,6 N-acetylglucosaminyltransferase V (Mgat5) is up-regulated in carcinomas
and promotes the substitution of N-glycan with poly N-acetyllactosamine, the preferred …

Sequence analysis revealed phospholipase A 2 (PLA 2 ) motifs in capsid proteins of
parvoviruses. Although PLA 2 activity is not known to exist in viruses, putative PLA 2 s from …

… protein complex functions to regulate caveolae expression and caveolin function is a
field of active investigation that should provide important new insight into caveolae function (Nabi, …

Background Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that
relays nutrient availability signals to control numerous cellular functions including autophagy, …

The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …

Glycosylation is a common posttranslational modification of proteins and lipids of the secretory
pathway that generates binding sites for galactose-specific lectins or galectins. Branching …

Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding partners that
is associated with cell surface caveolae and the regulation of lipid raft domains. Cav1 …