The unfolded protein response (UPR) is an intracellular signaling pathway that is activated
by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). UPR activation …

Recent progress in the synthesis and characterization of metal–organic frameworks (MOFs)
has opened the door to an increasing number of possible catalytic applications. The great …

Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation
from naïve T-cells into appropriate effector cells. Because of their fundamental roles in …

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded
protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits …

Throughout their life, cells must maintain homeostasis while facing constantly fluctuating
demands on their different organelles. A major mechanism for the homeostatic control of …

Introduction The androgen receptor (AR) is widely expressed in breast cancers and has been
proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast cancers …

Endocytosis functions to recycle plasma membrane components, to regulate cell-surface
expression of signalling receptors and to internalize nutrients in all eukaryotic cells. …

Government policies currently commit us to surface warming of three to four degrees
Celsius above pre-industrial levels by 2100, which will lead to enhanced ice-sheet melt. Ice-sheet …

Background Biological considerations suggest that renin–angiotensin system inhibitors
might influence the severity of COVID-19. We aimed to evaluate whether continuing versus …

Developing supported single-site catalysts is an important goal in heterogeneous catalysis
since the well-defined active sites afford opportunities for detailed mechanistic studies, …