The melanocortin system refers to a set of hormonal, neuropeptidergic, and paracrine
signaling pathways that are defined by components that include the five G protein-coupled …

The central melanocortin system is perhaps the best-characterized neuronal pathway involved
in the regulation of energy homeostasis. This collection of circuits is unique in having the …

Oral delivery is the most common method for drug administration. However, poor solubility,
stability, and bioavailability of many drugs make achieving therapeutic levels via the …

… and then wrote to Cone, giving him my impressions and stressing the importance of its
immediate publication in Latin America, because black theology, of which Cone was the foremost …

… As both a theologian and a Black preacher, Cone not only brought the full weight of that
Western theological tradition to bear, but he also brought his experiences as a Black …

The melanocortin-4 receptor (MC4-R) is a G protein–coupled, seven-transmembrane receptor
expressed in the brain. Inactivation of this receptor by gene targeting results in mice that …

… and the resulting reaction of the black community, Cone wrote: “This work…is written with
a … But in this text, Cone is dealing with not just the death of Martin, nor just the death of so …

Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide
Y (NPY) systems in the arcuate nucleus 1 . The NPY Y2 receptor (Y2R), a putative inhibitory …

The administration of leptin 1 to leptin-deficient humans, and the analogous Lep ob /Lep ob
mice, effectively reduces hyperphagia and obesity 2 , 3 . But common obesity is associated …

DOMINANT alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a
consequence of ectopic expression of the agouti peptide 1–6 . This peptide, normally only …