A novel class of aspartic peptidases known as fungal yapsins, whose first member ScYps1p
was identified more than a decade ago in Saccharomyces cerevisiae, is characteristically …

10.7554/eLife.27860.001 Recent functional, proteomic and ribosome profiling studies in
eukaryotes have concurrently demonstrated the translation of alternative open-reading frames (…

The maintenance of duplicated genes is thought to protect cells from genetic perturbations,
but the molecular basis of this robustness is largely unknown. By measuring the interaction of …

Since deleterious mutations may be rescued by secondary mutations during evolution,
compensatory evolution could identify genetic solutions leading to therapeutic targets. Here, we …

Cellular processes and homeostasis control in eukaryotic cells is achieved by the action of
regulatory proteins such as protein kinase A (PKA). Although the outbound signals from PKA …

Gene duplication is ubiquitous and a major driver of phenotypic diversity across the tree of
life, but its immediate consequences are not fully understood. Deleterious effects would …

The evolution of protein-coding genes proceeds as mutations act on two main dimensions:
regulation of transcription level and the coding sequence. The extent and impact of the …

Little is known about the rate of emergence of de novo genes, what their initial properties are,
and how they spread in populations. We examined wild yeast populations (…

10.7554/eLife.46754.001 Gene duplication is a driver of the evolution of new functions. The
duplication of genes encoding homomeric proteins leads to the formation of homomers and …

Whole-genome duplication (WGD) followed by speciation allows us to examine the parallel
evolution of ohnolog pairs. In the yeast family Saccharomycetaceae, HRR25 is a rare case of …