Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is
caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an …

Ceramide is one of the major sphingosine-based lipid second messengers that is generated
in response to various extracellular agents. However, while widespread attention has …

Tumor necrosis factor alpha (TNF)-dependent modulation of immune responses and cell
death processes has long been the subject of intense research. Yet, its role in cancer …

The nature of the signaling pathway(s) which initiate drug‐triggered apoptosis remains
largely unknown and is of fundamental importance in understanding cell death induced by …

Tumor necrosis factor-α (TNFα)-induced cell death involves a diverse array of mediators and
regulators including proteases, reactive oxygen species, the sphingolipid ceramide, and Bcl…

The oral Bruton’s tyrosine kinase inhibitor, ibrutinib, has recently demonstrated high efficiency
in patients with relapsed B-cell malignancies. Occurrence of bleeding events has been …

Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment
for melanoma. However, many patients do not display therapeutic response or eventually …

Macroautophagy is a vacuolar lysosomal catabolic pathway that is stimulated during
periods of nutrient starvation to preserve cell integrity. Ceramide is a bioactive sphingolipid …

The sphingolipid ceramide induces macroautophagy (here called autophagy) and cell death
with autophagic features in cancer cells. Here we show that overexpression of sphingosine …

Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired
intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in the …