Osteoclasts are the cells responsible for physiological bone resorption. A specific organization
of their most prominent cytoskeletal structures, podosomes, is crucial for the degradation …

Rheumatoid arthritis is characterized by synovial inflammation and irreversible bone erosions,
both highlighting the immense reciprocal relationship between the immune and bone …

Over the past two decades, the field of osteoimmunology has emerged in response to a
range of evidence demonstrating the reciprocal relationship between the immune system and …

In most animal species, juvenile growth is marked by an exponential gain in body weight
and size. Here we show that the microbiota of infant mice sustains both weight gain and …

Background information. Sema‐7A is a glycosylphosphatidylinositol‐anchored semaphorin
that was first identified in the immune system. It is a member of a large family of proteins …

The function of osteoclasts is to digest the calcified bone matrix. Osteoclasts, together with
myotubes, are among the rare examples of multinucleated cells found in higher vertebrates, …

Osteoporosis is one of the most common bone pathologies, which are characterized by a
decrease in bone mass. It is well established that bone mass, which results from a balanced …

The semaphorin-signaling transducer collapsin response mediator protein 2 (CRMP2) has
been identified in the nervous system where it mediates Sema3A-induced growth cone …

Bone metastasis affects >70% of patients with advanced breast cancer. However, the molecular
mechanisms underlying this process remain unclear. On the basis of analysis of clinical …

Lysophosphatidic acid (LPA) is a natural bioactive lipid that acts through six different G
protein-coupled receptors (LPA 1–6 ) with pleiotropic activities on multiple cell types. We have …