Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring
…, F Desarnaud, HN Bader, I Makotkine… - American Journal of …, 2014 - Am Psychiatric Assoc
Objective Differential effects of maternal and paternal posttraumatic stress disorder (PTSD)
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
[HTML][HTML] Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD
…, NP Daskalakis, F Desarnaud, I Makotkine… - Frontiers in …, 2013 - frontiersin.org
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known
whether these measures associate with, or predict, clinical state. These questions were …
whether these measures associate with, or predict, clinical state. These questions were …
Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder
…, A Lehrner, F Desarnaud, I Makotkine… - Biological …, 2015 - Elsevier
Background Enhanced glucocorticoid receptor (GR) sensitivity is present in people with
posttraumatic stress disorder (PTSD), but the molecular mechanisms of GR sensitivity are not …
posttraumatic stress disorder (PTSD), but the molecular mechanisms of GR sensitivity are not …
Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks
MN Hill, LM Bierer, I Makotkine, JA Golier… - …, 2013 - Elsevier
Endocannabinoid (eCB) signaling has been identified as a modulator of adaptation to stress,
and is integral to basal and stress-induced glucocorticoid regulation. Furthermore, …
and is integral to basal and stress-induced glucocorticoid regulation. Furthermore, …
Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress
…, D Abu-Amara, M Coy, TC Neylan, I Makotkine… - Brain, behavior, and …, 2014 - Elsevier
Background Chronic inflammation may be involved in combat-related post-traumatic stress
disorder (PTSD) and may help explain comorbid physical diseases. However, the extent to …
disorder (PTSD) and may help explain comorbid physical diseases. However, the extent to …
Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: Randomized trial showing improved treatment retention and …
Background Prolonged exposure (PE) therapy for post-traumatic stress disorder (PTSD) in
military veterans has established efficacy, but is ineffective for a substantial number of patients…
military veterans has established efficacy, but is ineffective for a substantial number of patients…
Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors
…, IR Harris, A Bedi, NP Daskalakis, I Makotkine… - …, 2014 - Elsevier
Intergenerational effects of trauma have been observed clinically in a wide range of populations,
and parental PTSD has been associated with an increased risk for psychopathology in …
and parental PTSD has been associated with an increased risk for psychopathology in …
[HTML][HTML] Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
…, J Goldberg, F Desarnaud, I Makotkine… - Nature …, 2022 - nature.com
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent
to which genetic and environmental risk factors contribute to individual clinical outcomes is …
to which genetic and environmental risk factors contribute to individual clinical outcomes is …
Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001
BACKGROUND: A proportion of subjects with symptoms of posttraumatic stress disorder (PTSD)
are unresponsive to specialized psychotherapy, but a biological basis for this has not …
are unresponsive to specialized psychotherapy, but a biological basis for this has not …
Increased pro-inflammatory milieu in combat related PTSD–a new cohort replication study
…, LM Bierer, D Abu-Amara, M Coy, I Makotkine… - Brain, behavior, and …, 2017 - Elsevier
Introduction Several lines of evidence indicate that increased inflammation is associated
with Post-Traumatic Stress Disorder (PTSD). We have previously reported that peripheral …
with Post-Traumatic Stress Disorder (PTSD). We have previously reported that peripheral …