Embryogenesis is supported by dynamic loops of cellular interactions. Here, we create a
partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic …

The early mammalian conceptus (blastocyst) contains two supporting extraembryonic
tissues-the trophectoderm and the primitive endoderm (PrE)-that encase and guide the epiblast (…

The early mammalian conceptus (blastocyst) contains two supporting extraembryonic tissues
- the trophectoderm and the primitive endoderm (PrE) - that encase and guide the epiblast (…

Mammalian chromosomes are folded into an intricate hierarchy of structural domains, within
which topologically associating domains (TADs) and CTCF-associated loops partition the …

Hox genes play a fundamental role in anterior-posterior patterning and are remarkably
conserved throughout evolution (Slack et al., 1993). Their products are transcription factors that …

Studying the dynamics and epigenetic signatures of immune cells is important to understand
the differences in immune response of individuals. Vast amount of scRNA-seq and scATAC-…

The very first days of mammalian embryonic development are accompanied by epigenetic
reprogramming and extensive changes in nuclear organization. In particular, genomic regions …

Gastruloids are three-dimensional aggregates of embryonic stem cells that display key
features of mammalian development after implantation, including germ-layer specification and …

Recent studies identified rare missense mutations in amyotrophic lateral sclerosis (ALS)
patients in the TARDBP gene encoding TAR DNA binding protein (TDP)‐43, the major protein …

Major advances in Cell and Molecular Biology have been associated with the advances in
live-cell microscopy imaging, and these studies started to rely on temporal single cell imaging…