RNA silencing is a complex, highly conserved mechanism mediated by small RNAs (sRNAs),
such as microRNAs (miRNAs), that is known to be involved in a diverse set of biological …

Regulation of hematopoiesis during human development remains poorly defined. Here we
applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-…

The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis
in a paracrine manner through the senescence-associated secretory phenotype (SASP). …

The myeloid neoplasms encompass acute myeloid leukemia, myelodysplastic syndromes
and myeloproliferative neoplasms. Most cases arise from the shared ancestor of clonal …

Plants feature a particularly diverse population of short (s)RNAs, the central component of all
RNA silencing pathways. Next generation sequencing techniques enable deeper insights …

MicroRNAs negatively regulate the accumulation of mRNAs therefore when they are expressed
in the same cells their expression profiles show an inverse correlation. We previously …

Motivation RNA interference, a highly conserved regulatory mechanism, is mediated via
small RNAs (sRNA). Recent technical advances enabled the analysis of larger, complex …

Plants substantially alter their developmental programme upon changes in the ambient
temperature. The 21–24 nt small RNAs (sRNAs) are important gene expression regulators, …

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified
in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, …

Socio-sexual environments have profound effects on fitness. Local sex ratios can alter the
threat of sexual competition, to which males respond via plasticity in reproductive behaviors …