Introductions and early spread of SARS-CoV-2 in the New York City area

…, J Dutta, N Francoeur, BS Melo, I Oussenko… - Science, 2020 - science.org
New York City (NYC) has emerged as one of the epicenters of the current severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission …

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

…, K Venema, H Bolhuis, I Oussenko… - Proceedings of the …, 1996 - National Acad Sciences
Resistance of Lactococcus lactis to cytotoxic compounds shares features with the multidrug
resistance phenotype of mammalian tumor cells. Here, we report the gene cloning and …

[PDF][PDF] Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

…, D Fucich, MK Annavajhala, IN Khan, I Oussenko… - Cell metabolism, 2022 - cell.com
K. pneumoniae sequence type 258 (Kp ST258) is a major cause of healthcare-associated
pneumonia. However, it remains unclear how it causes protracted courses of infection in spite …

Engineering a humanized bone organ model in mice to study bone metastases

…, DJ Wu, CO Hutmacher, D Moi, T Oussenko… - Nature protocols, 2017 - nature.com
Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …

Analysis of mRNA decay in Bacillus subtilis

DH Bechhofer, IA Oussenko, G Deikus, S Yao… - Methods in …, 2008 - Elsevier
Studies of mRNA turnover in B. subtilis are less well known than in E. coli. Here we provide
researchers who have an interest in gram‐positive RNA processing with several protocols for …

Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

…, NE Zeitouni, DR Altman, E Webster, I Oussenko… - Nature …, 2020 - nature.com
Clostridioides (formerly Clostridium) difficile is a leading cause of healthcare-associated
infections. Although considerable progress has been made in the understanding of its genome, …

Participation of 3′-to-5′ Exoribonucleases in the Turnover of Bacillus subtilis mRNA

IA Oussenko, T Abe, H Ujiie, A Muto… - Journal of …, 2005 - Am Soc Microbiol
Four 3′-to-5′ exoribonucleases have been identified in Bacillus subtilis: polynucleotide
phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Mutant strains were constructed …

In-host population dynamics of Mycobacterium tuberculosis complex during active disease

…, L Freschi, M Marin, LE Epperson, M Smith, I Oussenko… - Elife, 2021 - elifesciences.org
Tuberculosis (TB) is a leading cause of death globally. Understanding the population dynamics
of TB’s causative agent Mycobacterium tuberculosis complex (Mtbc) in-host is vital for …

[HTML][HTML] Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts

…, ED Jong, JH Lee, M Massumi, T Oussenko… - Nature Biomedical …, 2023 - nature.com
The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the
advancement of cell therapies. Here we show that the overexpression of eight …

Bacillus subtilis YhaM, a Member of a New Family of 3′-to-5′ Exonucleases in Gram-Positive Bacteria

IA Oussenko, R Sanchez, DH Bechhofer - Journal of bacteriology, 2002 - Am Soc Microbiol
A strain of Bacillus subtilis lacking two 3′-to-5′ exoribonucleases, polynucleotide
phosphorylase (PNPase) and RNase R, was used to purify another 3′-to-5′ exoribonuclease, …