Massively parallel sequencing of cDNA has enabled deep and efficient probing of transcriptomes.
Current approaches for transcript reconstruction from such data often rely on aligning …

Cells, the basic units of biological structure and function, vary broadly in type and state.
Single-cell genomics can characterize cell identity and function, but limitations of ease and scale …

Spatial localization is a key determinant of cellular fate and behavior, but methods for spatially
resolved, transcriptome-wide gene expression profiling across complex tissues are lacking…

Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in which …

We recently showed that the mammalian genome encodes >1,000 large intergenic
noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene …

High-throughput single-cell transcriptomics offers an unbiased approach for understanding
the extent, basis and function of gene expression variation between seemingly identical cells…

Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
in fully vaccinated individuals are receiving intense scrutiny because of their importance in …

Our main result is a reduction from worst-case lattice problems such as GapSVP and SIVP
to a certain learning problem. This learning problem is a natural extension of the “learning …

Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …