Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of …

Background Some high-income countries have deployed fourth doses of COVID-19 vaccines,
but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain. We …

This article reviews current research and cross-disciplinary perspectives on the neuroscience
of food reward in animals and humans, examines the scientific hypothesis of food addiction…

Common mechanisms in aging and obesity are hypothesized to increase susceptibility to
neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We …

Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol
concentrations have been identified in several neurodegenerative disorders. Whether these …

Background: Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R)
gene is important in protecting against common obesity. Larger studies are needed, …

Importance Abnormal eating behaviors are common in patients with frontotemporal dementia
(FTD), yet their exact prevalence, severity, and underlying biological mechanisms are not …

Selenium is a trace element that is essential for human health and is incorporated into more
than 25 human selenocysteine-containing (Sec-containing) proteins via unique Sec-…

Context Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt
signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia and …

Context: Mutations that lead to congenital leptin deficiency cause severe obesity, hyperphagia,
and impaired satiety due to malfunctions of peripheral and brain-related mechanisms. …