Clinically feasible approaches to potentiating cancer cell-based immunotherapies

VI Seledtsov, AG Goncharov… - Human vaccines & …, 2015 - Taylor & Francis
The immune system exerts both tumor-destructive and tumor-protective functions. Mature
dendritic cells (DCs), classically activated macrophages (M1), granulocytes, B lymphocytes, aβ …

Analysis of canonical and non-canonical splice sites in mammalian genomes

M Burset, IA Seledtsov, VV Solovyev - Nucleic acids research, 2000 - academic.oup.com
A set of 43 337 splice junction pairs was extracted from mammalian GenBank annotated
genes. Expressed sequence tag (EST) sequences support 22 489 of them. Of these, 98.71% …

Assemblathon 1: a competitive assessment of de novo short read assembly methods

…, MT Dimon, V Solovyev, I Seledtsov… - Genome …, 2011 - genome.cshlp.org
Low-cost short read sequencing technology has revolutionized genomics, though it is only
just becoming practical for the high-quality de novo assembly of a novel large genome. We …

SpliceDB: database of canonical and non-canonical mammalian splice sites

M Burset, IA Seledtsov, VV Solovyev - Nucleic acids research, 2001 - academic.oup.com
A database (SpliceDB) of known mammalian splice site sequences has been developed.
We extracted 43 337 splice pairs from mammalian divisions of the gene-centered Infogene …

A balance between tissue-destructive and tissue-protective immunities: a role of toll-like receptors in regulation of adaptive immunity

VI Seledtsov, GV Seledtsova - Immunobiology, 2012 - Elsevier
The immune system has been shown to be involved in not only the host defense against
infectious pathogens but also in tissue repair processes continuously occurring in the body. Our …

Alignathon: a competitive assessment of whole-genome alignment methods

…, RS Harris, S Fitzgerald, K Beal, I Seledtsov… - Genome …, 2014 - genome.cshlp.org
Multiple sequence alignments (MSAs) are a prerequisite for a wide variety of evolutionary
analyses. Published assessments and benchmark data sets for protein and, to a lesser extent, …

Cell therapy of brain stroke

SS Rabinovich, VI Seledtsov, NV Banul… - Bulletin of experimental …, 2005 - Springer
Cell suspension consisting of cells from immature nervous and hemopoietic tissues was
subarachnoidally transplanted to 10 patients with brain stroke consequences. Clinical effect of …

Oxygen therapy in traditional and immunotherapeutic treatment protocols of cancer patients: Current reality and future prospects

VI Seledtsov, AA von Delwig - Expert Review of Anticancer …, 2022 - Taylor & Francis
Introduction The metabolic environment in ischemic and hypoxic tumors is known to contribute
to cancer progression. Importantly, peculiar metabolic changes occurring in malignant …

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia–reperfusion injury in mice

…, IA Schepetkin, AI Khlebnikov, VI Seledtsov… - Neuroscience …, 2016 - Elsevier
The c-Jun N-terminal kinase (JNK) has been shown to be an important regulator of
neuronal cell death. Previously, we synthesized the sodium salt of 11H-indeno[1,2-b]quinoxalin-11-…

Interleukin-8 favors pro-inflammatory activity of human monocytes/macrophages

…, AG Goncharov, GV Seledtsova, VI Seledtsov - International …, 2018 - Elsevier
Interleukin-8 (IL-8, CXCL8) belongs to major chemokines to stimulate migration of neutrophils
and monocytes/macrophages (Mc/Mphs) into the inflammation sites. We studied the direct …