Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To
address advances in oncology, molecular biology, pathology, radiology, and surgery of lung …

The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura,
Thymus and Heart has just been published with numerous important changes from the 2004 …

Gallbladder cancer is usually associated with gallstone disease, late diagnosis, unsatisfactory
treatment, and poor prognosis. We report here the worldwide geographical distribution of …

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …

Immune-checkpoint inhibitors targeting PD-1 or PD-L1 have already substantially improved
the outcomes of patients with many types of cancer, although only 20–40% of patients derive …

Importance Targeting oncogenic drivers (genomic alterations critical to cancer development
and maintenance) has transformed the care of patients with lung adenocarcinomas. The …

Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of
targeted therapies 2 and the development of high-resolution, genome-wide approaches 3 , 4 , …

Background Non-small-cell lung cancer (NSCLC) is terminal in most patients with locally
advanced stage disease. We aimed to assess the antitumour activity and safety of neoadjuvant …

KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously
reported that STK11/LKB1 (KL) or TP53 (KP) comutations define distinct subgroups of …