… Iain Chalmers, coordinator2 … Progress has been made towards reducing the 85% of
wasted effort in medical research—and the huge amounts of money misspent and harm …

Continuing differences of opinion among obstetricians and neonatologists about the place
of corticosteroid administration before preterm delivery have prompted us to carry out a …

Science is supposed to be cumulative, but scientists only rarely cumulate evidence scientifically.
This means that users of research evidence have to cope with a plethora of reports of …

Objective. —To determine if inadequate approaches to randomized controlled trial design
and execution are associated with evidence of bias in estimating treatment effects. Design. —…

Without accessible and usable reports, research cannot help patients and their clinicians. In
a published Personal View, 1 a medical researcher with myeloma reflected on the way that …

The increase in annual global investment in biomedical research—reaching US$240 billion
in 2010—has resulted in important health dividends for patients and the public. However, …

Background Post-partum haemorrhage is the leading cause of maternal death worldwide.
Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We …

… Iain Chalmers … Iain Chalmers … Chalmers TC (1975) Effects of ascorbic acid on the
common cold. An evaluation of the evidence. Am J Med 58: 532-536. …

Comment 102 www. thelancet. com Vol 383 January 11, 2014 from governments, which are
run, at least partly, by politicians. The success of funding policy, and the job security of the …

Ed Iain Chalmers, Douglas G Altman BMJ Publishing Group,£ 14.95, pp 1 19 ISBN 0 7279
0904 5 sr T_he function of the expert reviewer is not to be more right than other people, but to …