The microtubule-binding interface of the kinetochore is of central importance in chromosome
segregation. Although kinetochore components that stabilize, translocate on, and affect the …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed of a …

The Aurora kinase Ipl1p plays a crucial role in regulating kinetochore-microtubule attachments
in budding yeast, but the underlying basis for this regulation is not known. To identify …

Accurate chromosome segregation requires carefully regulated interactions between kinetochores
and microtubules, but how plasticity is achieved to correct diverse attachment defects …

In vertebrates, centromeres lack defined sequences and are thought to be propagated by
epigenetic mechanisms involving the incorporation of specialized nucleosomes containing the …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for more …

Kinetochores play an essential role in chromosome segregation by forming dynamic
connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore …

Regulated interactions between kinetochores and spindle microtubules are essential to
maintain genomic stability during chromosome segregation. The Aurora B kinase …

Kinetochore specification and assembly requires the targeted deposition of specialized
nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is …

Maintaining genome integrity during cell division requires regulated interactions between
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …