Even among genetically identical cancer cells, resistance to therapy frequently emerges from
a small subset of those cells 1 , 2 , 3 , 4 , 5 , 6 – 7 . Molecular differences in rare individual …

These data shed light on the mechanochemical interactions that occur between aged skin,
tumor, and immune cell populations, which may affect tumor metastasis and immune cell …

COVID-19 vaccines have recently been updated to specifically encode or contain the spike
protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet …

The SARS-CoV-2 omicron lineage (B. 1.1. 529) continues to proliferate and evolve, leading
to subvariants adept at evading antibody responses. 1 Bivalent mRNA vaccines expressing …

Methods for detecting single nucleic acids in cell and tissues, such as fluorescence in situ
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe binding…

Conditional mutagenesis is becoming a method of choice for studying gene function, but
constructing conditional alleles is often laborious, limited by target gene structure, and at times, …

SARS-CoV-2 Omicron BA.2.75 has diversified into multiple subvariants with additional spike
mutations and several are expanding in prevalence, particularly CH.1.1 and BN.1. Here, we …

Cellular plasticity describes the ability of cells to transition from one set of phenotypes to
another. In melanoma, transient fluctuations in the molecular state of tumor cells mark the …

Even amongst genetically identical cancer cells, therapy resistance often only emerges from
a very small subset of those cells. Much effort has gone into uncovering the molecular …

Background Cardiac differentiation of human-induced pluripotent stem (hiPS) cells consistently
produces a mixed population of cardiomyocytes and non-cardiac cell types, even when …