Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons 1 , 2 , 3 , 4 – 5 . …

In response to pathogenic threats, naive T cells rapidly transition from a quiescent to an
activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed …

Regulatory T (T reg ) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity 1 . Conversely, T reg instability, …

Despite recent advances in medical technology and a global effort to improve public health
and hygiene, parasitic infections remain a major health and economic burden worldwide. …

Regulatory T cells (Tregs) are required to control immune responses and maintain
homeostasis but are a significant barrier to anti-tumor immunity 1 . Conversely, Treg instability, …

Tightly regulated immune responses are required to recognize and eliminate pathogenic
threats while mitigating collateral damage to host-tissues. In mammals, CD4+ and CD8+ T cells …

Regulatory T cells (Tregs) are required to control immune responses and maintain
homeostasis but are a significant barrier to anti-tumor immunity1. Conversely, Treg instability, …

Decades of work have elucidated cytokine signalling and transcriptional pathways that control
T cell differentiation and have led the way to targeted biologic therapies that are effective …

Recent success in identifying gene-regulatory elements in the context of recombinant adeno-associated
virus vectors has enabled cell-type-restricted gene expression. However, within …

Antibiotic treatment has emerged as a promising strategy to sterilize and kill filarial nematodes
due to their dependence on their endosymbiotic bacteria, Wolbachia. Several studies …