The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally
distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and …

Almost all of the key molecules involved in the innate and adaptive immune response are
glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding, …

Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global
health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (…

Influenza virus presents an important and persistent threat to public health worldwide, and
current vaccines provide immunity to viral isolates similar to the vaccine strain. High-affinity …

The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19),
manifesting with respiratory symptoms and multi-organ dysfunction. Detailed …

Immune recognition of protein antigens relies on the combined interaction of multiple antibody
loops, which provide a fairly large footprint and constrain the size and shape of protein …

Continuously emerging highly pathogenic human coronaviruses (HCoVs) remain a major
threat to human health, as illustrated in past SARS-CoV and MERS-CoV outbreaks. The …

Certain human pathogens avoid elimination by our immune system by rapidly mutating the
surface protein sites targeted by antibody responses, and consequently they tend to be …

Factors that inhibit the amplification of nucleic acids by PCR are present with target DNAs
from many sources. The inhibitors generally act at one or more of three essential points in the …

Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …