User profiles for Ian P Wicks
 | Ian WicksOther name: Ian P Wicks Walter & Eliza Hall Institute Verified email at wehi.edu.au Cited by 13719 |
[HTML][HTML] RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might …
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might …
Interleukin‐6 modulates production of T lymphocyte–derived cytokines in antigen‐induced arthritis and drives inflammation‐induced osteoclastogenesis
…, IK Campbell, IP Wicks - … : Official Journal of …, 2006 - Wiley Online Library
Objective To determine the cellular mediators of antigen‐induced arthritis (AIA) and the
relative contribution of members of the interleukin‐6 (IL‐6) family and tumor necrosis factor (TNF) …
relative contribution of members of the interleukin‐6 (IL‐6) family and tumor necrosis factor (TNF) …
[PDF][PDF] TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells
Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense
but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the …
but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the …
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma
Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer,
ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little …
ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little …
Targeting GM-CSF in inflammatory diseases
IP Wicks, AW Roberts - Nature Reviews Rheumatology, 2016 - nature.com
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth factor first identified
as an inducer of differentiation and proliferation of granulocytes and macrophages derived …
as an inducer of differentiation and proliferation of granulocytes and macrophages derived …
Collagen‐induced arthritis in C57BL/6 (H‐2b) mice: new insights into an important disease model of rheumatoid arthritis
…, JA Hamilton, IP Wicks - European journal of …, 2000 - Wiley Online Library
Collagen‐induced arthritis (CIA) is a widely used model of rheumatoid arthritis (RA) and has
been important for understanding autoimmunity. CIA is purportedly restricted to mice …
been important for understanding autoimmunity. CIA is purportedly restricted to mice …
G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis
…, BS McKenzie, S Chatfield, IP Wicks - Nature Reviews …, 2009 - nature.com
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating
factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an …
factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an …
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure …
The receptor subunit gp130 transduces multiple cell type–specific activities of the leukemia
inhibitory factor (LIF)/interleukin (IL)-6 family of cytokines through the signal transducer and …
inhibitory factor (LIF)/interleukin (IL)-6 family of cytokines through the signal transducer and …
Granulocyte colony-stimulating factor and neutrophils—forgotten mediators of inflammatory disease
JL Eyles, AW Roberts, D Metcalf, IP Wicks - Nature clinical practice …, 2006 - nature.com
Recent studies have highlighted the functional capacity of neutrophils as powerful mediators
of tissue inflammation. Granule-packaged proteases and reactive oxygen intermediates, …
of tissue inflammation. Granule-packaged proteases and reactive oxygen intermediates, …
[HTML][HTML] SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1–dependent inflammatory arthritis
…, WS Alexander, AW Roberts, IP Wicks - The Journal of …, 2006 - Am Soc Clin Investig
RA is an autoimmune disease characterized by sustained imbalance between pro- and
antiinflammatory immune mechanisms. The SOCS proteins are negative regulators of cytokine …
antiinflammatory immune mechanisms. The SOCS proteins are negative regulators of cytokine …