Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD)
can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (…

Human cancers harbour numerous mutations and it has been proposed that these result from
some form of inherent genomic instability. Some cancers have proven genomic instability …

Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is
known about their etiology and pathogenesis 1, 2, 3. We previously mapped a gene that …

Familial juvenile polyposis is an autosomal dominant disease characterized by a predisposition
to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a subset of …

Background Germ-line mutations in the base-excision–repair gene MYH have been
associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected …

In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor …

Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly influence the risk of developing colorectal cancer (CRC). To enhance power to …

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that
catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible for …

The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is
therefore a form of evolution at the somatic level, in which the population is comprised of …