Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system
…, DG Ward, M Jamshad, V Spana, IT Cadby… - Nature …, 2019 - nature.com
The Mla pathway is believed to be involved in maintaining the asymmetrical Gram-negative
outer membrane via retrograde phospholipid transport. The pathway is composed of three …
outer membrane via retrograde phospholipid transport. The pathway is composed of three …
[HTML][HTML] Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus
C Lambert, IT Cadby, R Till, NK Bui, TR Lerner… - Nature …, 2015 - nature.com
Predatory Bdellovibrio bacteriovorus are natural antimicrobial organisms, killing other bacteria
by whole-cell invasion. Self-protection against prey-metabolizing enzymes is important for …
by whole-cell invasion. Self-protection against prey-metabolizing enzymes is important for …
[HTML][HTML] Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria
…, J Biboy, A Wilson, IT Cadby… - Nature …, 2022 - nature.com
Peptidoglycan hydrolases contribute to the generation of helical cell shape in Campylobacter
and Helicobacter bacteria, while cytoskeletal or periskeletal proteins determine the curved, …
and Helicobacter bacteria, while cytoskeletal or periskeletal proteins determine the curved, …
[HTML][HTML] Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
RW Meek, IT Cadby, PJ Moynihan… - Nature communications, 2019 - nature.com
The bacterial second messenger cyclic-di-GMP is a widespread, prominent effector of lifestyle
change. An example of this occurs in the predatory bacterium Bdellovibrio bacteriovorus, …
change. An example of this occurs in the predatory bacterium Bdellovibrio bacteriovorus, …
[HTML][HTML] Coordinated response of the Desulfovibrio desulfuricans 27774 transcriptome to nitrate, nitrite and nitric oxide
IT Cadby, M Faulkner, J Cheneby, J Long… - Scientific Reports, 2017 - nature.com
The sulfate reducing bacterium Desulfovibrio desulfuricans inhabits both the human gut and
external environments. It can reduce nitrate and nitrite as alternative electron acceptors to …
external environments. It can reduce nitrate and nitrite as alternative electron acceptors to …
[HTML][HTML] CdbA is a DNA-binding protein and c-di-GMP receptor important for nucleoid organization and segregation in Myxococcus xanthus
…, W Steinchen, D Szadkowski, IT Cadby… - Nature …, 2020 - nature.com
Cyclic di-GMP (c-di-GMP) is a second messenger that modulates multiple responses to
environmental and cellular signals in bacteria. Here we identify CdbA, a DNA-binding protein of …
environmental and cellular signals in bacteria. Here we identify CdbA, a DNA-binding protein of …
[HTML][HTML] The hydrolase LpqI primes mycobacterial peptidoglycan recycling
PJ Moynihan, IT Cadby, N Veerapen, M Jankute… - Nature …, 2019 - nature.com
Growth and division by most bacteria requires remodelling and cleavage of their cell wall. A
byproduct of this process is the generation of free peptidoglycan (PG) fragments known as …
byproduct of this process is the generation of free peptidoglycan (PG) fragments known as …
Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48 metalloprotease BepA
The asymmetric Gram-negative outer membrane (OM) is the first line of defense for bacteria
against environmental insults and attack by antimicrobials. The key component of the OM is …
against environmental insults and attack by antimicrobials. The key component of the OM is …
Regulation, sensory domains and roles of two Desulfovibrio desulfuricans ATCC27774 Crp family transcription factors, HcpR1 and HcpR2, in response to nitrosative …
In silico analyses identified a Crp/Fnr family transcription factor (HcpR) in sulfate‐reducing
bacteria that controls expression of the hcp gene, which encodes the hybrid cluster protein …
bacteria that controls expression of the hcp gene, which encodes the hybrid cluster protein …
Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase
IT Cadby, SM Basford, R Nottingham, R Meek… - The EMBO …, 2019 - embopress.org
Bacterial usage of the cyclic dinucleotide c‐di‐ GMP is widespread, governing the transition
between motile/sessile and unicellular/multicellular behaviors. There is limited information …
between motile/sessile and unicellular/multicellular behaviors. There is limited information …