Understanding brain function requires monitoring local and global brain dynamics. Two-photon
imaging of the brain across mesoscopic scales has presented trade-offs between …

Monitoring spiking activity across large neuronal populations at behaviorally relevant
timescales is critical for understanding neural circuit function. Unlike calcium imaging, voltage …

Optical coherence tomography (OCT) is an emerging 3D imaging technique that allows
quantification of intrinsic optical properties such as scattering coefficient and back-scattering …

Brain cells are arranged in laminar, nuclear, or columnar structures, spanning a range of
scales. Here, we construct a reliable cell census in the frontal lobe of human cerebral cortex at …

Animal models of stroke are used extensively to study the mechanisms involved in the acute
and chronic phases of recovery following stroke. A translatable animal model that closely …

Objective: Serial sectioning optical coherence tomography (OCT) enables accurate volumetric
reconstruction of several cubic centimeters of human brain samples. We aimed to identify …

The cerebral cortex is organized in cortical layers that differ in their cellular density,
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …

Wavelength conversion (WC) imaging is a methodology that employs temperature sensitive
detectors to convert photoinduced termperature into a detectable optical signal. One specific …

Significance: The optical properties of biological samples provide information about the
structural characteristics of the tissue and any changes arising from pathological conditions. …

The study of aging and neurodegenerative processes in the human brain requires a
comprehensive understanding of cytoarchitectonic, myeloarchitectonic, and vascular structures. …