Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins
ISB Larsen, Y Narimatsu, HJ Joshi… - Proceedings of the …, 2017 - National Acad Sciences
The cadherin (cdh) superfamily of adhesion molecules carry O-linked mannose (O-Man)
glycans at highly conserved sites localized to specific β-strands of their extracellular cdh (EC) …
glycans at highly conserved sites localized to specific β-strands of their extracellular cdh (EC) …
[HTML][HTML] Mapping the O-mannose glycoproteome in Saccharomyces cerevisiae
…, A Essig, HJ Joshi, E Zatorska, ISB Larsen… - Molecular & Cellular …, 2016 - ASBMB
O-Mannosylation is a vital protein modification conserved from fungi to humans. Yeast is a
perfect model to study this post-translational modification, because in contrast to mammals O-…
perfect model to study this post-translational modification, because in contrast to mammals O-…
Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast
A Halim, ISB Larsen, P Neubert… - Proceedings of the …, 2015 - National Acad Sciences
Dynamic cycling of N-Acetylglucosamine (GlcNAc) on serine and threonine residues (O-GlcNAcylation)
is an essential process in all eukaryotic cells except yeast, including …
is an essential process in all eukaryotic cells except yeast, including …
Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2
BM Adams, NP Canniff, KP Guay, ISB Larsen… - Elife, 2020 - elifesciences.org
UDP-glucose:glycoprotein glucosyltransferase (UGGT) 1 and 2 are central hubs in the
chaperone network of the endoplasmic reticulum (ER), acting as gatekeepers to the early …
chaperone network of the endoplasmic reticulum (ER), acting as gatekeepers to the early …
Multiple distinct O-Mannosylation pathways in eukaryotes
Protein O-mannosylation (O-Man), originally discovered in yeast five decades ago, is an
important post-translational modification (PTM) conserved from bacteria to humans, but not …
important post-translational modification (PTM) conserved from bacteria to humans, but not …
The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase
ISB Larsen, L Povolo, L Zhou, W Tian… - Proceedings of the …, 2023 - National Acad Sciences
Mutations in the TMEM260 gene cause structural heart defects and renal anomalies syndrome,
but the function of the encoded protein remains unknown. We previously reported wide …
but the function of the encoded protein remains unknown. We previously reported wide …
[HTML][HTML] Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2
Protein O-mannosylation is found in yeast and metazoans, and a family of conserved
orthologous protein O-mannosyltransferases is believed to initiate this important post-translational …
orthologous protein O-mannosyltransferases is believed to initiate this important post-translational …
Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation
…, K Mathavan, E Weir, ISB Larsen… - Molecular Biology of …, 2020 - Am Soc Cell Biol
Protein glycosylation plays essential roles in protein structure, stability, and activity such as
cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose …
cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose …
A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion
…, P Reis-Rodrigues, K Shkarina, ISB Larsen… - Elife, 2019 - elifesciences.org
10.7554/eLife.41801.001 Aberrant display of the truncated core1 O-glycan T-antigen is a
common feature of human cancer cells that correlates with metastasis. Here we show that T-…
common feature of human cancer cells that correlates with metastasis. Here we show that T-…
ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation
…, JC Sunryd, K Mathavan, E Weir, I Signe, B Larsen… - bioRxiv, 2019 - Am Soc Cell Biol
Protein glycosylation plays essential roles in protein structure, stability and activity such as
cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose …
cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose …