Biological, clinical and population relevance of 95 loci for blood lipids
…, J Tuomilehto, JR Thompson, T Tanaka, I Surakka… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
The impact of low-frequency and rare variants on lipid levels
Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes
Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, …
Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Meta-analysis of genome-wide association studies in> 80 000 subjects identifies multiple loci for C-reactive protein levels
Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …
strongly associated with cardiovascular disease. We sought to identify genetic variants that …
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of …
…, E Tikkanen, J Kettunen, I Surakka… - Circulation …, 2012 - Am Heart Assoc
Background— Genome-wide association (GWA) studies have identified several susceptibility
loci for metabolic syndrome (MetS) component traits, but have had variable success in …
loci for metabolic syndrome (MetS) component traits, but have had variable success in …
[PDF][PDF] Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Meta-analysis is pervasively used to combine multiple genome-wide association studies (GWASs).
Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …