N6-methyladenosine in poly(A) tails stabilize VSG transcripts

IJ Viegas, JP de Macedo, L Serra, M De Niz… - Nature, 2022 - nature.com
RNA modifications are important regulators of gene expression 1 . In Trypanosoma brucei,
transcription is polycistronic and thus most regulation happens post-transcriptionally 2 . N 6 -…

From trans-splicing discovery and onwards, trypanosomes lead the way

IJ Viegas, LM Figueiredo - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Viegas and Figueiredo tell us how, among several molecular and biochemical discoveries,
RNA trans-splicing was discovered in trypanosomes.

m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle

L Serra, S Silva Pereira, I Viegas, H Machado… - bioRxiv, 2024 - biorxiv.org
N6-methyladenosine (m6A) is a mRNA modification with important roles in gene expression.
In African trypanosomes, this post-transcriptional modification is detected in hundreds of …

[PDF][PDF] N6-methyladenosine, a new modification in T. brucei epitranscriptome

IJC Viegas - 2014 - run.unl.pt
Idálio de Jesus Contreiras ViegasIdálio de Jesus Contreiras Viegas … These base J binding
proteins are required for the synthesis of base J. (Borst and Sabatini, 2008). In Leishmania, …

Characterisation of the role of the ATR kinase homolog in L. major response to replication stress

GLA Silva - 2022 - teses.usp.br
Eukaryotic cells have evolved mechanisms to maintain and replicate their genomes, whose
integrity and transmission are constantly challenged by DNA damage and replication …

Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes

MF Fidalgo, CG Fonseca, P Caldas… - Life Science …, 2022 - life-science-alliance.org
Adaptation to breathing is a critical step in lung function and it is crucial for organismal survival.
Alveoli are the lung gas exchange units and their development, from late embryonic to …

Alternative splicing changes are associated with pre-birth adaptation during lung development

MF Fidalgo, CG Fonseca, P Caldas, AASF Raposo… - bioRxiv, 2022 - biorxiv.org
Gas exchanges are ensured by lung alveoli, which are mainly composed by epithelial alveolar
type 1 (AT1), alveolar type 2 (AT2) and capillary endothelial cells (ECs). Alveologenesis …

[PDF][PDF] Operation and Exploitation of the Reactor, Dosimetry (RPI) and Reactor Calculations

AC FERNANDES, JP SANTOS, A KLING - parameters, 2004 - ctn.tecnico.ulisboa.pt
… CHU, Methods for the mitigation of the chemical reactivity of beryllium in steam, J. Nucl. Mat.
… MARTINS, The characterization of silicon carbide films and their use in color sensor, J. Mat. …

Homeostasis and response of IL-17-producing γδ T cells in peripheral tissues

PH Papotto - 2019 - repositorio.ul.pt
… E, guiados pelo Vasc(ã)o (Conceição) eo Idálio (Viegas), pudemos começar a explorar
cantos recônditos do Bairro Alto ao Cais do Sodré e presenciar o Emanuel (Fernandes) dançar …

Epigenetic Clocks and Programmatic Aging

D Gems, RS Virk, JP de Magalhães - 2023 - preprints.org
The last decade has seen remarkable progress in the characterization of methylation clocks
that track biological age in humans and many other mammalian species. While the …