Gene editing by CRISPR/Cas9 is commonly used to generate germline mutations or perform
in vitro screens, but applicability for in vivo screening has so far been limited. Recently, it …

Developmental neuronal remodeling is an evolutionarily conserved mechanism required for
precise wiring of nervous systems. Despite its fundamental role in neurodevelopment and …

During development, neurons switch among growth states, such as initial axon outgrowth,
axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila …

Tauopathies, such as Alzheimer’s disease (AD), are a group of disorders characterized
neuropathologically by intracellular toxic accumulations of abnormal protein aggregates formed …

Alzheimer's disease (AD) is the most abundant tauopathy and is characterized by Aβ-derived
plaques and tau-derived tangles, resulting from the unfolding of the corresponding …

The mechanisms controlling wiring of neuronal networks are not completely understood. The
stereotypic architecture of the Drosophila mushroom body (MB) offers a unique system to …

Intrinsic neurite growth potential is a key determinant of neuronal regeneration efficiency
following injury. The stereotypical remodeling of Drosophila γ-neurons includes developmental …

Precise connectivity of neurites to subcellular domains is a conserved feature of complex
circuits, but the mechanisms defining precise wiring are largely unknown. The Drosophila …

Developmental neuronal remodeling is an evolutionarily conserved mechanism required for
accurate wiring of mature nervous systems across animal kingdom. Following the initial …

… A reduction in chitin would prove valuable for optimizing aquaculture feed, says Idan
Alyagor, FreezeM co-founder and Chief Technology Officer. …