INTRODUCTION The nucleus harbors and protects the genetic information in eukaryotes. It
is surrounded by the nuclear envelope, which separates the nucleoplasm from the cytosol. …

Lamella micromachining by focused ion beam milling at cryogenic temperature (cryo-FIB) has
matured into a preparation method widely used for cellular cryo-electron tomography. Due …

Cryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of
macromolecular assemblies in their native cellular context. However, the localization of …

Spatially controlled cell adhesion on electron microscopy supports remains a bottleneck in
specimen preparation for cellular cryo-electron tomography. Here, we describe contactless …

Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of
meiosis is preceded by an extended prophase in which homologous chromosomes undergo …

Meiosis consists of DNA replication followed by two consecutive nuclear divisions and
gametogenesis or spore formation. While meiosis I has been studied extensively, less is known …

Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial
tetrameric protein complex. Although inorganic phosphate (Pi) is known to promote GLS …

Negative-stranded RNA viruses can establish long-term persistent infection in the form of
large intracellular inclusions in the human host and cause chronic diseases. Here, we uncover …

Biogenic crystals present a variety of complex morphologies that form with exquisite fidelity.
In the case of the intricate morphologies of coccoliths, calcite crystals produced by marine …

Genome haploidization involves sequential loss of cohesin from chromosome arms and
centromeres during two meiotic divisions. At centromeres, cohesin's Rec8 subunit is protected …