Reactive oxygen species (ROS) are essential components of the innate immune response
against intracellular bacteria and it is thought that professional phagocytes generate ROS …

Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. By
generation of mice in which inflammasome expression is restricted to IECs, we describe a …

Bacterial pathogens utilize pore-forming toxins or specialized secretion systems to deliver
virulence factors to modulate host cell physiology and promote bacterial replication. Detection …

Toll-like receptor signaling and subsequent activation of NF-κB– and MAPK-dependent genes
during infection play an important role in antimicrobial host defense. The YopJ protein of …

Infections have been proposed as initiating factors for inflammatory disorders; however,
identifying associations between defined infectious agents and the initiation of chronic disease …

Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly cleaves …

The development and severity of inflammatory bowel diseases and other chronic inflammatory
conditions can be influenced by host genetic and environmental factors, including signals …

Innate immune detection of nucleic acids is important for initiation of antiviral responses.
Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-…

White adipose tissue bridges body organs and plays a fundamental role in host metabolism.
To what extent adipose tissue also contributes to immune surveillance and long-term …

Host defence against microbial pathogens requires appropriate coordination of multiple
signalling pathways. These pathways are triggered by innate immune recognition of conserved …