Background Misfolding and pathological aggregation of neuronal proteins has been proposed
to play a critical role in the pathogenesis of neurodegenerative disorders. Alzheimer's …

“Liquid biopsy” approaches analyzing cell-free DNA (cfDNA) from the blood of patients with
cancer are increasingly utilized in clinical practice. However, it is not yet known whether …

Parkinson’s disease (PD) and dementia with Lewy bodies are common disorders of the aging
population and characterized by the progressive accumulation of α‐synuclein (α‐syn) in …

Accumulation of α‐synuclein resulting in the formation of oligomers and protofibrils has been
linked to Parkinson's disease and Lewy body dementia. In contrast, β‐synuclein (β‐syn), a …

Untargeted metabolomics on the plasma and urine from wild-type and organic anion
transporter-1 (Oat1/Slc22a6) knockout mice identified a number of physiologically important …

Abnormal accumulation and propagation of the neuronal protein α-synuclein has been
hypothesized to underlie the pathogenesis of Parkinson’s disease, dementia with Lewy bodies …

… Igor F Tsigelny Igor F Tsigelny … Tsigelny is an expert in structural biology, molecular
modeling, bioinformatics, structure-based drug design and personalized medicine. He published >…

A cell-based high-throughput screen to identify small molecular weight stimulators of the
innate immune system revealed substituted pyrimido[5,4-b]indoles as potent NFκB activators. …

Background Because imaging has a high sensitivity to diagnose hepatocellular carcinoma (HCC)
and tissue biopsies carry risks such as bleeding, the latter are often not performed in …

Using the crystal structure of SARS-CoV-2 papain-like protease (PL pro) as a template, we
developed a pharmacophore model of functional centers of the PL pro inhibitor-binding …