Replicative senescence is an irreversible cell cycle arrest that limits the proliferation of
damaged cells and may be an important tumor suppression mechanism in vivo. This process is …

Background The tumor suppressor p53 is an important regulator that controls various
cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 …

Nicotinamide adenine dinucleotide (NAD), a cofactor for hundreds of metabolic reactions in
all cell types, plays an essential role in metabolism, DNA repair, and aging. However, how …

Inactivation of p53 and activation of telomerase occur in the majority of human cancers,
raising the possibility of a link between these two pathways. Overexpression of wild-type p53 …

Telomere shortening in primary human fibroblasts results in replicative senescence, which
can be overcome by telomerase (hTERT) overexpression. However, because immortalization …

Given the very substantial heterogeneity of most human cancers, it is likely that most cancer
therapeutics will be active in only a small fraction of any population of patients. As such, the …

Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported
to repress cancer growth and improve therapeutic responses in several preclinical settings. …

Methionine restriction, a dietary regimen that protects against metabolic diseases and aging,
represses cancer growth and improves cancer therapy. However, the response of different …

Hypoxic stress is one of the major selective pressures in the microenvironment of solid tumors,
and overcoming this restriction is essential for tumor progression. One of the key factors …

Prostate cancer is the most commonly diagnosed type of cancer in men, and there is no
available cure for patients with advanced disease. In vitro model systems are urgently required …