User profiles for Ijeoma Nwabudike

Ijeoma Nwabudike

Verified email at yale.edu
Cited by 155

[PDF][PDF] High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways

…, C Sakai, C Szi, B Rooney, M Ghosh, I Nwabudike… - Cell reports, 2023 - cell.com
Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

[PDF][PDF] ASICs mediate food responses in an enteric serotonergic neuron that controls foraging behaviors

JL Rhoades, JC Nelson, I Nwabudike, KY Stephanie… - Cell, 2019 - cell.com
Animals must respond to the ingestion of food by generating adaptive behaviors, but the
role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify …

[PDF][PDF] Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale

U Dag, I Nwabudike, D Kang, MA Gomes, J Kim… - Cell, 2023 - cell.com
Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse
receptors across the brain to modulate global activity and behavior is unknown. Here, we …

A neural circuit for flexible control of persistent behavioral states

…, A Dayan, CM Baker, TS Kramer, I Nwabudike… - Elife, 2021 - elifesciences.org
To adapt to their environments, animals must generate behaviors that are closely aligned to
a rapidly changing sensory world. However, behavioral states such as foraging or courtship …

Functional Analysis of Autism Genes in Zebrafish Identifies Convergence in Dopaminergic and Neuroimmune Pathways and Pharmacological Candidates.

…, C Szi, B Rooney, M Ghosh, I Nwabudike - Gazi Medical …, 2024 - search.ebscohost.com
A central challenge in the genetics of autism spectrum disorders (ASDs) is advancing from
gene discovery to the identification of actionable biological mechanisms. To investigate the …

Genetic and Neural Circuit Analyses of Sickness and Foraging Behaviors in C. elegans

GK Madan - 2024 - dspace.mit.edu
… D.; Talya Kramer for her perceptive takes on science and life in general; and Ijeoma
Nwabudike for her engaging company and wide-ranging discussions that often extended late into …

[PDF][PDF] Physicochemical properties, total concentration, geochemical fractions, and health risks of trace metals in oilbearing soils of Akwa Ibom State, Nigeria

GA Ebong, EA Moses, OA Akpabio… - Journal of Materials & …, 2022 - academia.edu
The physicochemical properties, total metal, metal fractions, and related human health
problems of metals in oilbearing soils of Akwa Ibom State were appraised using standard …

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes

X Jin, SK Simmons, A Guo, AS Shetty, M Ko, L Nguyen… - Science, 2020 - science.org
INTRODUCTION Human genetic studies have revealed long lists of genes and loci associated
with risk for many diseases and disorders, but to systematically evaluate their phenotypic …

Cell type-specific contributions to a persistent aggressive internal state in female Drosophila

H Chiu, AA Robie, KM Branson, T Vippa, S Epstein… - bioRxiv, 2023 - biorxiv.org
Persistent internal states are important for maintaining survival-promoting behaviors, such
as aggression. In female Drosophila melanogaster, we have previously shown that …

The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects

M Coll-Tané, NN Gong, SJ Belfer, LV van Renssen… - Science …, 2021 - science.org
Sleep disturbances in autism and neurodevelopmental disorders are common and adversely
affect patient’s quality of life, yet the underlying mechanisms are understudied. We found …