Adult mammalian testis is a source of pluripotent stem cells 1 . However, the lack of specific
surface markers has hampered identification and tracking of the unrecognized subset of …

Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion, although
the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (…

MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage
is critical for germ cell development. To identify meiotic piRNA targets, we augmented the …

Spermatogenesis is maintained by a pool of spermatogonial stem cells (SSCs). Analyses of
the molecular profile of SSCs have revealed the existence of subsets, indicating that the …

During development, mammalian germ cells reprogram their epigenomes via a genome-wide
erasure and de novo rewriting of DNA methylation marks. We know little of how …

The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity.
Following injury, it can regenerate almost an entirely new organism because of the presence of …

An economical and simplified procedure to derive and propagate fully functional lines of
undifferentiated rat spermatogonia in vitro is presented. The procedure is based on the …

In mammals, spermatogenesis is maintained by spermatogonial stem cells (SSC). In their
niche, SSC divide to self‐maintain and to produce a transit‐amplifying population that …

10.7554/eLife.47999.001 The PIWI-interacting RNA (piRNA) pathway is a small RNA-based
immune system that controls the expression of transposons and maintains genome integrity …

PIWI proteins and their associated piRNAs protect germ cells from the activity of mobile
genetic elements. Two classes of piRNAs—primary and secondary—are defined by their …